ZORVOLEX® Gives Patients With Mild to Moderate Acute Pain and OA Pain a Low-dose Treatment Option

    To learn more about NSAIDs and why low-dose NSAIDs are an important new development in treating mild to moderate acute pain and OA pain, click these links:

    ZORVOLEX® 18 mg: The Lowest FDA-approved Dose of Diclofenac Available

    ZORVOLEX® is the first US Food and Drug Administration (FDA) – approved low-dose SoluMatrix® diclofenac for mild to moderate acute pain and OA pain

    ZORVOLEX®: A Low-dose NSAID Option for Management of Mild to Moderate Acute Pain and Osteoarthritis (OA) Pain

    Iroko Pharmaceuticals, LLC, created ZORVOLEX® with appropriate patients in mind:

    • ZORVOLEX® is the first low-dose SoluMatrix® diclofenac – a trusted and commonly used NSAID for mild to moderate acute pain and OA pain
    • Low-dose SoluMatrix® NSAIDs were developed by Iroko to align with recommendations from FDA, medical organizations, and advocacy groups: use the lowest effective NSAID dose for the shortest period of time

    In addition to being the first low-dose SoluMatrix® diclofenac, data show ZORVOLEX®:

    • Effectively managed mild to moderate acute pain and OA pain at low doses
    • Was generally well tolerated
    ZORVOLEX® is FDA-approved at low 18-mg and 35-mg doses for the management of mild to moderate acute pain and OA pain.

    Iroko Pharmaceuticals, LLC,  created ZORVOLEX® with SoluMatrix Fine Particle Technology, an innovative scientific process that creates NSAID drug particles that are approximately 10- to 20-times smaller than their original size.

    • The result: low-dose NSAID pain medicine that is rapidly absorbed by the body
    Particle Chart

    Original NSAID particles

    SoluMatrix® NSAID particles

    Eligible* patients
    pay as little as
    $10

    *Terms and Conditions may apply.

    Looking for a low-dose NSAID option to manage mild to moderate acute pain and OA pain?

    Ask your doctor about ZORVOLEX®

    NSAIDs and the FDA: 
Warnings and Recommendations

    Over the past decade, the FDA has monitored and evaluated the safety of NSAIDs

    In 2005, based on new evidence about NSAID risks, the FDA began requiring manufacturers of prescription NSAIDs to include new safety warnings:

    • The boxed warning highlighted the potential for increased risk of serious cardiovascular (CV) events with these drugs and the well-described, serious, and potentially life-threatening gastrointestinal (GI) bleeding associated with their use
    • The FDA specifically recommended taking the lowest effective NSAID dose for the shortest period of time

    In July 2015, the FDA strengthened its warning about NSAID use to emphasize that patients taking NSAIDs are at greater risk for heart attack or stroke.

    Potential Risks With NSAIDs

    The higher the NSAID dose, the higher the risk of serious side effects.

    Risk of Heart Problems

    NSAID use may:

    Increase the chance of heart attack or stroke in people with or without heart disease or risk factors for heart disease

    Risk of Stomach and GI Problems

    NSAID use may:

    Increase the chance of bleeding, ulcers, and tears (perforations) of the esophagus (the tube leading from the mouth to the stomach), stomach, and intestines

    Risk of Kidney Problems

    NSAID use may:

    Increase the chance of kidney problems, including kidney failure and progressive kidney damage

    ZORVOLEX® matters because:

    Many patients treated for mild to moderate acute pain and OA pain are treated with an NSAID

    Diclofenac is a trusted NSAID that physicians have used for years to help patients with mild to moderate acute pain and OA pain

    Although data show diclofenac can help relieve mild to moderate acute pain and OA pain, they also show NSAIDs like diclofenac in high doses can increase risk of serious heart and stomach problems

    The higher the NSAID dose, the higher the risk of serious heart and stomach problems

    The FDA recommends that patients take the lowest effective NSAID dose for the shortest period of time.

    ZORVOLEX® 18 mg three times daily offers the lowest effective diclofenac dosage for managing mild to moderate acute pain.

    Looking for a low-dose NSAID option to manage mild to moderate acute pain or OA pain?

     

    Ask your doctor about ZORVOLEX®

    Eligible* patients pay as little as $10.

    *Terms and Conditions apply.

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