A pain reliever designed to
work effectively at low doses

Approved for patients with osteoarthritis (OA) pain* and mild to moderate acute pain

The first low-dose NSAID created using SoluMatrix Fine Particle Technology

  • NSAIDs (nonsteroidal anti-inflammatory drugs) are used to treat pain, redness, swelling, and inflammation
  • ZORVOLEX is an NSAID approved by the United States Food and Drug Administration (FDA), the agency that approves new drugs, for management of mild to moderate acute pain and OA pain
  • ZORVOLEX is available in low doses of 18 mg and 35 mg, dosage strengths that are not available for any other NSAID
  • The FDA states that ZORVOLEX should not be substituted for other diclofenac products; please ensure your pharmacist gives you ZORVOLEX

*ZORVOLEX 35 mg capsules taken orally three times a day is the approved dosage for the management of OA pain.


ZORVOLEX is a nonsteroidal anti-inflammatory drug (NSAID) indicated for management of mild to moderate acute pain and osteoarthritis (OA) pain.

Important Safety Information

All prescription Non-Steroidal Anti-Inflammatory Drugs (NSAIDs), like ZORVOLEX, may increase the chances of a heart attack or stroke that can lead to death. These chances increase with higher doses of NSAID medicines; and, generally, with longer periods of use of NSAID medicines; or in people who have heart disease.

ZORVOLEX should not be used right before or after a certain heart surgery called a “coronary artery bypass grafting (CABG).”

NSAID medicines can cause ulcers and bleeding in the stomach and intestines at any time during treatment. Ulcers and bleeding can happen without warning symptoms and may cause death. The chance of a person having bleeding or getting an ulcer increases with higher doses or prolonged use of NSAID medicines, taking other medicines called “corticosteroids” and “anticoagulants,” smoking, drinking alcohol, older age, or having poor health.

Tell your healthcare provider about all of your medical conditions, if you are pregnant or breastfeeding, and about all of the medicines you are taking because NSAIDs and some other medicines can interact with each other and cause serious side effects.

ZORVOLEX should not be taken in late pregnancy.

Do not take ZORVOLEX if you had an asthma attack, hives, or other allergic reaction with aspirin, or any other NSAID medicine.

Life threatening allergic reactions can occur with ZORVOLEX. Get help right away if you’ve had swelling of the face or throat or trouble breathing.

Other serious side effects of NSAIDs include: high blood pressure, heart failure causing swelling (fluid retention), kidney problems including kidney failure, low red blood cells, life-threatening skin reactions, and liver problems including liver failure. The most common side effects reported in studies using ZORVOLEX were swelling, nausea, headache, dizziness, vomiting, constipation, itching, diarrhea, gas, leg or foot pain, abdominal pain, stuffy or runny nose, abnormal blood tests, high blood pressure, and heartburn.

ZORVOLEX should be used exactly as prescribed, at the lowest dose possible, and for the shortest time needed for your treatment.

These are not all the side effects reported with ZORVOLEX. Talk to your healthcare provider or pharmacist for more information about NSAID medicines. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

Please see full Prescribing Information, including the Medication Guide.

SoluMatrix Fine Particle Technology™ is a trademark of iCeutica Inc., and the technology is licensed to Iroko for exclusive use in NSAIDs.